The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Толл-подобные рецепторы (TLRs) играют важную роль в индукции и регуляции врожденной иммунной системы или адаптивных иммунных ответах. Показано, что что генетическая изменчивость TLRs человека связана с ревматоидным артритом (РА). Целью настоящей работы было изучение корреляций между однонуклеотидным полиморфизмом в сигнальной трансдукции TLRs и генами предрасположенности к РА. G-тип IL-1RAP rs766442 могут быть генами, предохраняющими от РА, в то время как аллели T-типа IL-6R rs11265618 и IL-1RAP rs766442 могут быть генами чувствительности к РА. Изучение полиморфизма нуклеиновых кислот в сигнальном пути TLRs может внести вклад в выявление участия генов в механизмах приступов РА, раннюю диагностику и лечение РА.The study was supported by Shandong Province young scientist in incentive fund (Grant № 2006BS03018) and National Natural Science Foundation of China (Grant № 30801025)

Artificial Intelligence and Human Error Prevention: A Computer Aided Decision Making Approach: Final Report

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryFederal Aviation Administration / FA79-WA-436

Multilevel Semantic Analysis and Problem-Solving in the Flight Domain: Final Report: NASA Grant NCCI-52, July 11, 1981-July 10, 1982

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryNASA Grant NCCI-5

印刷術對世界文明發展的探討

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Investigation of a two-phase flow natural circulation loop with divergent microchannel evaporator

Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.The development of microelectronics is toward high performance, high efficiency and yet small size. Thermal management of microelectronics is of critical concern and significant interest. Microchannel boiling is an advanced cooling technology for high heat flux devices. The present study explores heat removal capability of a two-phase natural circulation loop with divergent microchannel evaporator. Our previous studies revealed that a diverging cross section design significantly could stabilize and enhance the heat transfer of flow boiling. The temperatures at the inlet and outlet of both evaporator and condensing units are measured to evaluate the heat removal capability of the loop. Moreover, the pressure changes through the downcomer and lower horizontal tube are both measured to deduce the flow rate through the loop based on the relationship between flow rate and pressure drop. This study uses the high speed video camera to capture the flow patterns in the evaporator and riser. The working fluid employed in the present study is ethanol, as its boiling temperature at atmospheric pressure is 78.4 ℃, which is below the temperature limit of the most microelectronic materials. The results show that the loop mass flow rate increases monotonically with increasing the heating power of the evaporator after boiling incipience. The current experimental results indicate that the highest base heat flux could achieve is about 105 kWm-2 with no sign of dry-out and it has great potential to reach a higher heat flux. Moreover, it is found that the loop instability appears at low heating powers after boiling begins, while it can be suppressed if the input power is higher than 20W. Indeed, the present two-phase natural circulation loop with divergent microchannel evaporator demonstrates stable circulation with high heat transfer capability.dc201

Flexible hydrogen fuel cell fabricated on paper with embedded aluminium foil

Direct hydrogen fuel cells are generally heavy and rigid systems based on metal or plastic materials, which are not suitable for various miniwatt and flexible devices. In this study, we have developed a lightweight and flexible fuel cell based on paper substrate embedded with an Al foil inside, which is used as an in-situ hydrogen source by reaction with an electrolyte solution during operation. Benefited from the inhibited hydroxyl transportation by the porous cellulose network, the vigorous Al corrosion reaction is well controlled even though strong alkaline electrolyte is adopted, so that the fuel cell can be discharged for more than 5 hours at 1 mA cm-2 (0.83 V) with only 3.5 mg Al foil. The corresponding faradaic and energy efficiencies are as high as 72% and 18.3%, respectively. The fuel cell flexibility is also quite good when facing different bending angles. Considering its moderate power output, this flexible paper-based hydrogen fuel cell is especially suitable for powering various miniwatt and flexible devices, such as wearable electronics, biosensors, RFID tags, etc. However, higher power can be obtained by suitable stacking of the fuel cell

Stacking Sequence Effect on the Fracture Behavior of Narrow L-Shaped Cross-Ply Laminates: Experimental Study

The stacking sequence effect of narrow L-shaped laminates on the fracture mode was studied.Изучено влияние последовательности упаковки узкого уголка из ламинатов на характер его разрушения

Theory of the Quantum Hall Smectic Phase II: Microscopic Theory

We present a microscopic derivation of the hydrodynamic theory of the Quantum Hall smectic or stripe phase of a two-dimensional electron gas in a large magnetic field. The effective action of the low energy is derived here from a microscopic picture by integrating out high energy excitations with a scale of the order the cyclotron energy.The remaining low-energy theory can be expressed in terms of two canonically conjugate sets of degrees of freedom: the displacement field, that describes the fluctuations of the shapes of the stripes, and the local charge fluctuations on each stripe.Comment: 20 pages, RevTex, 3 figures, second part of cond-mat/0105448 New and improved Introduction. Final version as it will appear in Physical Review

Artificial Intelligence and Human Error Prevention: A Computer Aided Decision Making Approach: Technical Report No. 4: Survey and Analysis of Research on Learning Systems from Artificial Intelligence

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryU.S. Department of Transportation / DOT FA79WA-4360 ABFederal Aviation Administratio

The phase diagram of quantum systems: Heisenberg antiferromagnets

A novel approach for studying phase transitions in systems with quantum degrees of freedom is discussed. Starting from the microscopic hamiltonian of a quantum model, we first derive a set of exact differential equations for the free energy and the correlation functions describing the effects of fluctuations on the thermodynamics of the system. These equations reproduce the full renormalization group structure in the neighborhood of a critical point keeping, at the same time, full information on the non universal properties of the model. As a concrete application we investigate the phase diagram of a Heisenberg antiferromagnet in a staggered external magnetic field. At long wavelengths the known relationship to the Quantum Non Linear Sigma Model naturally emerges from our approach. By representing the two point function in an approximate analytical form, we obtain a closed partial differential equation which is then solved numerically. The results in three dimensions are in good agreement with available Quantum Monte Carlo simulations and series expansions. More refined approximations to the general framework presented here and few applications to other models are briefly discussed.Comment: 17 pages, 7 figure